Endocrine Abstracts

Introduction and objectives: Multiple surgeries are associated with many complications in the local recurrence of papillary thyroid carcinoma. Our objective is to evaluate the efficiency of the enolization in the recurrent metastatic cervical lymph nodes in patients with limited nodal disease.Material and methods: We studied 13 patients (six males and seven females) with a mean age of 43±14.4 years with papillary thyroid carcinoma intervened (total ...

Introduction: Endoscopic transsphenoidal pituitary surgery has become the first line method for removal pituitary tumours. A new way to see the surgical field and the cooperation of two neurosurgeons has supposed a revolution in the area.Objetives: Analyse surgical outcomes and complications of a cohort of patients from a single center who underwent ETPS for Cushing disease.Methods: Descriptive prospective-retrospective study inclu...

Introduction: Endoscopic transsphenoidal pituitary surgery has become the first line method for removal pituitary tumours. A new way to see the surgical field and the cooperation of two neurosurgeons has supposed a revolution in the area.Objetives: Analyse surgical outcomes and complications of a cohort of patients from a single center who underwent ETPS for GH secreting pituitary tumours.Methods: Descriptive prospective-retrospect...

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...

Introduction: Nowadays, use of chemotherapy in well-differentiated non medullary thyroid cancer, locally advanced stage and/or with radioiodine-refractory metastases is considered of scanty value. However, in the last 40 years was not published any phase III study nor a systematic review of its use in clinical setting.Methods: A systematic literature search was performed in databases such as Medline and Embase, among others. Two independent reviewers ana...

Introduction and objectives: The localization of primary hyperaldosteronism is often difficult. The coexistence of nonfunctioning adenomas is common in patients older 40 years old and small adenomas undetectable by CT could confuse with bilateral hyperplasia. The AVS is considered the ‘gold standard’ test for the location of numerous guides. We describe our experience in a clinical case of primary aldosteronism.Clinical case: We present a 58 ye...

Introduction: Everolimus is a drug selective inhibitor of mTOR. In 2012 a Phase 2 study* of everolimus monotherapy demonstrated modest efficacy in patients with pheochromocytomas/paragangliomas. Our objective was to evaluate the efficacy and safety of everolimus in a patient with paraganglioma. (*Phase 2 study of everolimus monotherapy in patient with nonfunctioning neuroendocrine tumor or pheochromocytomas/paraglangliomas. Do-Young Oh et al. Cancer 2012 <str...

Background: Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PCC/PGL) are the main components of MEN1 and MEN2, respectively. Although the presence of both tumors (3P association, 3PAs) in the same patient could be as a result of coincidence, at least in some cases, a common pathogenic mechanism has been involved. Recently has been confirmed that germline mutations in genes coding succinate dehydrogenase (SDH) play a role in pituitary tumorigenesis. Furthermore, M...

Objectives: Examine the relationship between choroidal thickness (CT) and renal function tests.Methods: Cross-sectional study with 42 eyes of 21 ocular treatment-naïve diabetic patients. Demographic and ocular data were analyzed as well as the following renal function tests: microalbuminuria, microalbumin/creatinine ratio and glomerular filtration rate (CKD-EPI and MDRD-4). Choroidal thickness was measured by swept-source ocular coherence tomography...

Aim: To assess whether E-cadherin expression levels in somatotropinomas were associated with the response to somatostatin analogues (SSAs) therapy in patients with acromegaly.Methods: In this retrospective study, 56 acromegaly patients that underwent transsphenoidal surgery were evaluated. All patients were treated preoperatively with SSAs (octreotide or lanreotide) for at least 6 months. Responsiveness to SSAs was evaluated by percent IGF-1 reduction af...